Topic 49: Olefin metathesis

49.1What is an olefin?
 
49.2What is a carbene? (see Section 24.4, first paragraph only)
 
49.3What is a transition metal—carbene complex?
 
49.4What, effectively, does olefin metathesis do?
 
49.5What is ring closing metathesis, and why is it so cool?
 
49.6What is the generally accepted four-step catalytic cycle mechanism for olefin metathesis, starting with a transition metal—carbene complex?
 

Topic 50: Organometallic reactions involving palladium

50.1What is a ligand?
 
50.2What is a precatalyst?
 
50.3What is ligand dissociation?
 
50.4What is ligand exchange?
 
50.5What is transmetalation?
 
50.6What is oxidative addition? (And where have you seen it before?)
 
50.7What is reductive elimination?
 

Topic 51: Suzuki coupling (aka Suzuki-Miyaura reaction)

51.1What is a vinylboronic ester and how is it made?
 
51.2What is an arylboronic ester, and how is it made?
 
51.3What two types of compounds are coupled in a Suzuki coupling?
 
51.4What does it mean to say that the Suzuki-Miyaura reaction with a vinyl halide is stereospecific?
 
51.5What is the generally accepted four-step catalytic cycle mechanism for a Suzuki coupling, starting with the active catalyst, Pd(PPH3)2, written simply as “Pd0”? [indicate oxidation state of Pd at each point in the mechanism]
 
51.6What are the names of the four steps in the generally accepted mechanism of a Suzuki coupling, in order.
 
51.7What is the role of NaOH in this reaction?
 
20 questions
472 questions for Organic II

472 Questions for Organic II

Dearest Student. This web page is a set of questions I call Detailed Intended Learning Outcomes For Organic Chemistry (Part II). Some time ago I asked myself, "Bob, what do you think are the key questions that you hope students will be able to answer after taking Chemistry 248 at St. Olaf College?" So here you have them. Some are very simple; some require more thought. All are good questions to be thinking about as you read, discuss, and master the practical aspects of organic chemistry. They are discussion starters and review tips. There are no answers here (though there are some clues). The questions are here to help you focus on what's important (to me, at least!) and organize your learning process. The questions are grouped into topics. Bite-size chunks. Take them a few at a time. Don't feast on them all at one sitting!

(preliminary version 2021.01.15 feeback: Bob Hanson)